| 发明名称 | 替比夫定一水合物化合物 | ||
| 摘要 | 本发明属于医药技术领域，具体涉及替比夫定一水合物晶体及其制备方法，本发明得到的替比夫定一水合物，具有的优点：纯度高；稳定性好，即使在高湿度条件下吸湿增重也不明显。本发明还涉及使用这种水合物的组合物治疗慢性乙型肝炎的应用。 | ||
| 申请公布号 | CN104650168A | 申请公布日期 | 2015.05.27 |
| 申请号 | CN201310593358.5 | 申请日期 | 2013.11.23 |
| 申请人 | 天津市汉康医药生物技术有限公司 | 发明人 | 严洁;李轩 |
| 分类号 | C07H19/073(2006.01)I;C07H1/00(2006.01)I;A61K31/7072(2006.01)I;A61P1/16(2006.01)I;A61P31/20(2006.01)I | 主分类号 | C07H19/073(2006.01)I |
| 代理机构 | 代理人 | ||
| 主权项 | 式Ⅰ所示替比夫定一水合物的晶体，<img file="2013105933585100001dest_path_image001.GIF" wi="243" he="169" /> （Ⅰ）所述替比夫定一水合物晶体，用CuKa射线作为特征X射线粉末测定中，其图谱具有下列2θ衍射角，晶面间距(d值)和相对强度（I/I<sub>0</sub>），<tables num="0001" id="ctbl0001"><table><tgroup cols="4"><colspec colname="c001" colwidth="23%" /><colspec colname="c002" colwidth="27%" /><colspec colname="c003" colwidth="24%" /><colspec colname="c004" colwidth="24%" /><tbody><row><entry morerows="1">No.</entry><entry morerows="1">2θ</entry><entry morerows="1">d（Å）</entry><entry morerows="1">I/I<sub>0</sub></entry></row><row><entry morerows="1">1</entry><entry morerows="1">9.653</entry><entry morerows="1">17.8456</entry><entry morerows="1">11</entry></row><row><entry morerows="1">2</entry><entry morerows="1">10.259</entry><entry morerows="1">9.5115</entry><entry morerows="1">8</entry></row><row><entry morerows="1">3</entry><entry morerows="1">13.587</entry><entry morerows="1">7.8754</entry><entry morerows="1">15</entry></row><row><entry morerows="1">4</entry><entry morerows="1">18.989</entry><entry morerows="1">6.1024</entry><entry morerows="1">9</entry></row><row><entry morerows="1">5</entry><entry morerows="1">21.874</entry><entry morerows="1">5.2458</entry><entry morerows="1">100</entry></row><row><entry morerows="1">6</entry><entry morerows="1">23.869</entry><entry morerows="1">5.1474</entry><entry morerows="1">35</entry></row><row><entry morerows="1">7</entry><entry morerows="1">25.758</entry><entry morerows="1">5.0147</entry><entry morerows="1">87</entry></row><row><entry morerows="1">8</entry><entry morerows="1">27.398</entry><entry morerows="1">4.8745</entry><entry morerows="1">6</entry></row><row><entry morerows="1">9</entry><entry morerows="1">28.958</entry><entry morerows="1">4.6587</entry><entry morerows="1">3</entry></row><row><entry morerows="1">10</entry><entry morerows="1">30.874</entry><entry morerows="1">4.0125</entry><entry morerows="1">20</entry></row><row><entry morerows="1">11</entry><entry morerows="1">31.285</entry><entry morerows="1">3.9668</entry><entry morerows="1">10</entry></row><row><entry morerows="1">12</entry><entry morerows="1">31.956</entry><entry morerows="1">3.8241</entry><entry morerows="1">9</entry></row><row><entry morerows="1">13</entry><entry morerows="1">32.654</entry><entry morerows="1">3.7587</entry><entry morerows="1">11</entry></row><row><entry morerows="1">14</entry><entry morerows="1">32.668</entry><entry morerows="1">3.6014</entry><entry morerows="1">13</entry></row><row><entry morerows="1">15</entry><entry morerows="1">34.845</entry><entry morerows="1">3.5894</entry><entry morerows="1">6</entry></row><row><entry morerows="1">16</entry><entry morerows="1">36.158</entry><entry morerows="1">3.4715</entry><entry morerows="1">28</entry></row><row><entry morerows="1">17</entry><entry morerows="1">37.578</entry><entry morerows="1">3.4510</entry><entry morerows="1">30</entry></row><row><entry morerows="1">18</entry><entry morerows="1">38.785</entry><entry morerows="1">3.2589</entry><entry morerows="1">16</entry></row><row><entry morerows="1">19</entry><entry morerows="1">40.584</entry><entry morerows="1">3.1124</entry><entry morerows="1">10</entry></row><row><entry morerows="1">20</entry><entry morerows="1">43.048</entry><entry morerows="1">2.1024</entry><entry morerows="1">15</entry></row></tbody></tgroup></table></tables>2θ衍射角的误差为±0.2。 | ||
| 地址 | 300409 天津市北辰区北辰科技园区华实道88号 | ||