发明名称 分岐型両親媒性ブロックポリマーを用いた分子集合体及び薬剤搬送システム
摘要 The present invention provides a molecular assembly whose retention time in a target site is adjusted depending on the kind or purpose of a labeling agent or drug encapsulated therein, and a molecular assembly that can suppress the ABC phenomenon and that can be administered more than once within a short span. A molecular assembly comprising: a branched-type amphiphilic block polymer A comprising a branched hydrophilic block comprising sarcosine and a hydrophobic block comprising a polylactic acid chain; and a functional substance F comprising a functional site and a polylactic acid chain, wherein the polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises L-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises D-lactic acid units, or the Polylactic acid chain constituting the hydrophobic block of the amphiphilic block polymer A comprises D-lactic acid units, and the polylactic acid chain contained in the functional substance F comprises L-lactic acid units.
申请公布号 JP5723074(B2) 申请公布日期 2015.05.27
申请号 JP20140534370 申请日期 2013.09.03
申请人 株式会社島津製作所;国立大学法人京都大学 发明人 原 功;小関 英一;木村 俊作;牧野 顕
分类号 A61K47/34;A61K9/51;A61K47/48;A61K49/00 主分类号 A61K47/34
代理机构 代理人
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