发明名称 |
CHARGE TRIGGERING OF SELF-ORGANIZED NANOPARTICLES |
摘要 |
The present application discloses a nanoparticle comprising compounds of the formula A-B-C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least −2 at pH 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least −1 at pH 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal. |
申请公布号 |
EP2709589(A4) |
申请公布日期 |
2015.05.27 |
申请号 |
EP20120785999 |
申请日期 |
2012.05.16 |
申请人 |
DANMARKS TEKNISKE UNIVERSITET |
发明人 |
JØLCK, RASMUS IRMING;HENRIKSEN, JONAS, ROSAGER;GJETTING, TORBEN;ANDRESEN, THOMAS, LARS |
分类号 |
A61K9/107;A61K9/127 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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