| 摘要 |
FIELD: medicine, pharmaceutics.SUBSTANCE: invention relates to compounds of formula (I) and their pharmaceutically acceptable salts, possessing antagonistic activity with respect to P2X- and/or P2X-receptor. In formulaR, Rand Rrepresent (a) Rand R, taken together, represent =Z; =Z represents =O; Rstands for group, represented by R; Rrepresents hydrogen, substituted or non-substituted Calkyl, Calkenyl, Ccycloalkyl; or (b) Rand Rtogether form bond; Rstands for group, represented by group -Y-R; Rrepresents substituted or non-substituted Calkyl, benzyl; -Y- represents -O-, -S-, -N(R)- or -CH-; Rrepresents hydrogen, substituted or non-substituted Calkyl or Rand Rtogether form substituted with oxogroup 5-membered nitrogen-containing non-aromatic heterocyclic group; n represents integer number, equal 1 or 2; Rrepresents substituted or non-substituted Ccycloalkyl, substituted or non-substituted phenyl or substituted or non-substituted 5-6-membered heteroaryl, containing one heteroatom, selected from N and S; Rrepresents group, represented by formula:where A ring represents Ccycloalkyl; 6-membered non-aromatic heterocyclic group, containing 1-2 heteroatoms, independently selected from N and O; phenyl; 5-6-membered heteroaryl, containing 1-2 heteroatoms, independently selected from N and O, substituted with oxogroup 9-membered heteroaryl, containing 1-2 heteroatoms, independently selected from N and O; s represents integer number from 0 to 2; values of the remaining radicals are presented in invention formula. Invention also relates to pharmaceutical composition, to application of compounds in obtaining medication for treatment and/or prevention of disease, associated with P2X- and/or P2X-receptor, and to method of treating and/or prevention of disease, associated with P2X- and/or P2X-receptor.EFFECT: obtained are compounds, which can be used in treatment and/or prevention of diseases, associated with P2X- and/or P2X-receptor.18 cl, 123 tbl, 29 ex |
