Bone graft materials containing calcium phosphate and chitosan

摘要

Described herein are materials and methods for increasing the osteoconductivity of a bone graft material, reducing the risk of infection at a surgical site, and increasing hemostasis. The bone graft materials described herein contain calcium phosphate and a form of chitin. In another embodiment the bone graft materials further comprises collagen. Chitin has been demonstrated to provide increased rate of new calcium phosphate growth, increased hemostasis, as well as antimicrobial properties. Various methods for manufacturing the bone graft materials described herein are also contemplated.

主权项

1. A method for preparing a biocompatible bone graft material comprising calcium phosphate, chitosan, and, optionally, collagen comprising:
making a solution of acid in water; adding chitosan to the acid solution to create a slurry; incubating the slurry for 0.5 hour to about 5 days; optionally, adjusting the pH of the slurry with a base to a pH of 4 to 8; adding calcium phosphate and, optionally, collagen to the slurry to create a second slurry; incubating the second slurry for 1 hour to about 24 hours to form an incubated second slurry; drying the incubated second slurry to form a biocompatible bone graft material; and, optionally, washing the biocompatible bone graft material.