发明名称 |
Monoclonal antibodies against alpha-actinin-4 antigens, and uses therefor |
摘要 |
Monoclonal antibodies (MoAbs or mAbs) specific for ALPHA-ACTININ-4 antigens, hybridoma lines that secrete these ALPHA-ACTININ-4 mAbs, and the use of such mAbs to detect ALPHA-ACTININ-4 antigens, particularly those expressed by cancer cells are disclosed. Chimeric and humanized antibodies based upon these anti-ALPHA-ACTININ-4 mAbs, processes for producing monoclonal, chimeric, and humanized antibodies using recombinant DNA technology, and their therapeutic uses, particularly in the treatment of cancer are also disclosed. Methods and kits for the immunodetection and immunotherapy of cells for samples which express ALPHA-ACTININ-4 antigens are additionally disclosed. |
申请公布号 |
US9040018(B2) |
申请公布日期 |
2015.05.26 |
申请号 |
US201113976811 |
申请日期 |
2011.12.23 |
申请人 |
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发明人 |
Alper Özge |
分类号 |
C07K16/18;G01N33/574 |
主分类号 |
C07K16/18 |
代理机构 |
Kenealy Vaidya LLP |
代理人 |
Kenealy Vaidya LLP |
主权项 |
1. An isolated antibody or antibody fragment that binds ALPHA-ACTININ-4, comprising a heavy chain variable domain comprising three complementary determining regions (CDRs) comprising the amino acid sequences of SEQ ID NO: 2, SEQ ID NO: 3, and SEQ ID NO: 4, and a light chain variable domain comprising three CDRs comprising the amino acid sequences of SEQ ID NO: 6, SEQ ID NO: 7; and SEQ ID NO: 8. |
地址 |
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