| 发明名称 |
Hydroxypropyl methyl cellulose acetate succinate with enhanced acetate and succinate substitution |
| 摘要 |
Disclosed are polymers of hydroxypropyl methyl cellulose acetate succinate (HPMCAS) with unique degrees of substitution of hydroxypropoxy, methoxy, acetyl, and succinoyl groups. When used in making compositions comprising a low-solubility active agent and such polymers, the polymers provide increased aqueous concentrations and/or improved physical stability of the active agent. |
| 申请公布号 |
US9040033(B2) |
申请公布日期 |
2015.05.26 |
| 申请号 |
US201113702331 |
申请日期 |
2011.06.13 |
| 申请人 |
|
发明人 |
Miller Warren K.;Lyon David K.;Friesen Dwayne T.;Caldwell William B.;Vodak David T.;Dobry Daniel E. |
| 分类号 |
A61K47/48;A61K9/14;A61K31/415;A61K31/496;C08B13/00;C08L1/32;A61K47/38 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A composition comprising:
an active agent; and hydroxypropyl methyl cellulose acetate succinate (HPMCAS) having a degree of substitution of methoxy groups (DSM) of ≦1.45, a degree of substitution of acetyl groups (DSAc) of from 1.0 to 1.5, and a combined degree of substitution of acetyl groups (DSAc) and succinoyl groups (DSS) of (DSAc+DSS)≧1.25. |
| 地址 |
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