Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium

摘要

A method and system are provided for determining a condition of a selected region of epithelial and stromal tissue in the human breast. A plurality of measuring electrodes are used to measure the tissue and transepithelial electropotential of breast tissue. Surface electropotential and impedance are also measured at one or more locations. An agent may be introduced into the region of tissue to enhance electrophysiological characteristics. The condition of the tissue is determined based on the electropotential and impedance profile at different depths of the epithelium, stroma, tissue, or organ, together with an estimate of the functional changes in the epithelium due to altered ion transport and electrophysiological properties of the tissue. Devices for practicing the disclosed methods are also provided.

主权项

1. An apparatus for determining the condition of an epithelial region of tissue comprising:
(A) a cup having an interior adapted to receive a volume of fluid, and first and second openings; (B) a current-passing electrode disposed within the interior; and (C) a source of suction connectable to the first opening; and wherein: (i) the first opening is adapted for connection to a source of fluid for introducing the fluid to the cup and alternatively to a source of suction; and (ii) the second opening is adapted for placement over a region of tissue; wherein the apparatus is adapted to make an electrical connection between the epithelial region of tissue to be examined and the electrode: (a) upon the application of suction to the first opening to seal the apparatus to a tissue surface: and (b) introduction of fluid to the interior of the cup through the first opening.