Silk polymer-based adenosine release: therapeutic potential for epilepsy

摘要

The invention provides formulations comprising adenosine in a silk fibroin-based, sustained-release delivery system. The formulations provide sustained, focal release of adenosine at therapeutic levels for the treatment of epilepsy and/or the prevention of epileptogenesis.

主权项

1. A biocompatible, biodegradable, sustained-release implantable pharmaceutical composition comprising adenosine in a silk fibroin-based, sustained-release delivery system, wherein the silk fibroin-based, sustained delivery system comprises adenosine-encapsulating microspheres embedded in a silk fibroin scaffold and wherein the scaffold further comprises adenosine which is not encapsulated in the microspheres, wherein upon implantation said implantable pharmaceutical composition has been shown in reference subjects to release from about 200 ng adenosine per day to about 10 mg adenosine per day, inclusive, for at least eight consecutive days.