发明名称 |
Enzyme combinations to reduce brain tissue swelling |
摘要 |
Tissue fixed charge density (FCD) is identified as another potential therapeutic target for reducing brain tissue swelling. Reduction of the FCD could reduce the thermodynamic force driving water entry into the brain. The present invention discloses chondroitinase ABC (ChABC) reduces tissue FCD and reduces tissue swelling, indicating that it may be an effective treatment to reduce edema and control intracranial pressure. |
申请公布号 |
US9040040(B2) |
申请公布日期 |
2015.05.26 |
申请号 |
US201313900755 |
申请日期 |
2013.05.23 |
申请人 |
The Trustees of Columbia University in the City of New York |
发明人 |
Elkin Benjamin Simon;Morrison, III Barclay;Finan John Desmond |
分类号 |
A61K38/46;A61K38/47;A61K38/51;A61K38/54 |
主分类号 |
A61K38/46 |
代理机构 |
Law Offices of Albert Wai-Kit Chan, PLLC |
代理人 |
Law Offices of Albert Wai-Kit Chan, PLLC |
主权项 |
1. A method of reducing brain tissue swelling in a subject in need thereof, comprising the step of administering to the subject a composition comprising an enzyme that digests chondroitin sulfate proteoglycans, an enzyme that digests heparin sulfate proteoglycans, and an enzyme that digests DNA. |
地址 |
New York NY US |