Device for removing protein-based substances

摘要

The present invention relates to a means of dialysis for removing protein-bound substances from a biological fluid, especially blood or blood plasma, which contains at least one means for solubilizing protein-binding substances to be removed into the biological fluid and/or dialysis fluid, and to a process for removing protein-bound substances from a biological fluid.

主权项

1. A method for dialysis of a biological fluid containing at least one protein-binding substance to be removed, comprising the following steps:
(a) passing the biological fluid through a first chamber of a first dialyser wherein the first chamber forms part of a biological fluid circuit, (b) passing a dialysis fluid containing a substance that functions as an adsorber for the substance to be removed from the biological fluid through a second chamber of the first dialyser wherein the second chamber forms part of a dialysis fluid circuit, (c) at least partially solubilizing the protein binding substance to be removed in the dialysis fluid by adjusting the pH of the dialysis fluid to 1-7 upstream of a second dialyser, (d) passing the dialysis fluid with the pH adjusted to 1-7 through the second dialyser forming part of the dialysis fluid circuit, and (e) adjusting the pH of the dialysis fluid to 8-13 downstream of the second dialyser.