| 发明名称 | Macromolecule transduction domains and methods for identification and uses thereof | ||
| 摘要 | The present invention discloses novel macromolecule transduction domain (MTD) peptides which facilitate the traverse of a biologically active molecule across the cell membrane. Also disclosed are polynucleotides encoding the MTD peptides, methods of identifying the MTD peptides; methods of genetically engineering a biologically active molecule to have cell permeability by using the MTD peptides, methods of importing a biologically active molecule into a cell by using the MTD peptides, and uses thereof. | ||
| 申请公布号 | US9040477(B2) | 申请公布日期 | 2015.05.26 |
| 申请号 | US201314091823 | 申请日期 | 2013.11.27 |
| 申请人 | PROCELL THERAPEUTICS INC. | 发明人 | Jo Dae Woong;Ko Jae Sun;Kim Jin Sook;Park Kyung Mi;Song Jin Kyung;Lim Jung Hee;Do Thi Thuy Nga;Do Thi Lan Phuong;Duong Minh Tam |
| 分类号 | C07K7/04;C07K7/06;C07K7/08;A61K47/48;C07K14/195;C07K14/47;A61K39/39;A61K48/00 | 主分类号 | C07K7/04 |
| 代理机构 | Oblon, McClelland, Maier & Neustadt, L.L.P. | 代理人 | Oblon, McClelland, Maier & Neustadt, L.L.P. |
| 主权项 | 1. An isolated macromolecule transduction domain (MTD) peptide wherein the peptide comprises the amino acid sequence selected from the group consisting of SEQ ID NOs: 123, 124, 156, and 173 wherein said MTD peptide comprises a single hydrophobic region at the N-terminus, forms a helix structure, exhibits flexibility, mediates transports of a biologically active molecule into a cell, and is 7 to 17 amino acids in length. | ||
| 地址 | Seoul KR | ||