GEM DIFLUORINATED C-GLYCOPEPTIDES, THEIR PREPARATION AND THEIR USE FOR THE PRESERVATION OF BIOLOGICAL MATERIALS AND/OR IN CRYOSURGERY

摘要

The invention concerns a gem-difluorinated C-glycopeptide compound of formula (I) in which N is an integer between 1 and 5, R4= H, AA1, AA1-AA2 and R5= OH, AA1, AA1.AA2, with AA1, and AA2 are independents and representing amino acids with a non-functionalised side chain and R1, R2, R3 are independent groups and one of them is egal to formula (II), in which n is an integer between 3 and 4, Y, Y' are independent groups in which Y, Y'= H, OR, N3, NR'R", SR~", where R = H, benzyl, trimethylsilyl, tert-butyldimethylsilyl, tert-butyldiphenylsilyl, acetate group, R', R" = H, alkyl, allyl, benzyl, tosylate group, C(=0)-alkyl, C(=O)-Bn, R"' = H, alkyl, acetate group, R6 is notably a group H, CH3, CH2OH, CH2-Glycoside group, CH2-OGP in which GP is a protector group such as an alkyl, benzyl, trimethylsilyl, tert-butyldimethylsilyl, tert~butyldiphenylsilyl, acetate group, and R7 = OH, OGP', NH2, N3, NHGP', NGP'GP" in which GP' and GP" is or not a protector group such as an alkyl, benzyl, trimethylsilyl, tert~butyldimethylsilyl, tert-butyldiphenylsilyl, acetate group, and RB is a hydrogen atom H or a free or protected alcohol function. It applies notably to preservation of biological materials and to cryosurgery.