Quantitative, non-invasive, clinical diagnosis of traumatic brain injury using VOG device for neurologic testing

摘要

A portable VOG device is disclosed that will facilitate the effective and efficient screening for TBI in military personnel in forward deployed military settings or remote locations using minimally trained staff. This includes the establishment of a protocol that will provide cost effective pre-screening of military personnel prior to deployment to establish a baseline of brain function prior to possible future injury. The efficiency of the device will promote subsequent follow-up screening to assess the effectiveness of prescribed TBI treatment. Further protocols for diagnosis and rehabilitation applications using the same virtual reality portable device will allow more advanced usage for clinicians providing ongoing evaluation and treatment.

主权项

1. A method of diagnosis of mild traumatic brain injury or concussion in a subject comprising the steps of:
A) providing a system including a stimulus generating portion and an eye tracking portion; B) presenting visual stimulus to the subject via the stimulus generating portion, wherein the visual stimulus presented to the subject via the stimulus generating portion forms the optical target stimulus for at least two distinct categories of tests including at least two from the following categories of tests i) nystagmus tests, ii) smooth pursuit tests, and iii) optokinetic tests; C) obtaining objective physiologic response of the subject in the form of reflexive responses and/or voluntary ocular-motor responses of the subject's eyes from the eye tracking portion based upon each of the visual stimulus presented to the subject in each test; and D) using the objective physiologic responses including the reflexive responses and/or voluntary ocular-motor responses of the subject's eyes to the optical target stimulus for at least two distinct categories of tests identified in step B) to diagnose the presence of mild traumatic brain injury or concussion.