Morphable logic gates using logical stochastic resonance in an engineered gene network

摘要

A method for providing a biological logic gate comprising the following steps: subjecting a bistable autoregulatory gene network (GRN) to a noisy background; identifying adjustable parameters of the GRN; using logical stochastic resonance to determine values of the GRN parameters which result in the GRN performing different logic gate functions; and setting the parameter values of the GRN such that the GRN performs a first logic gate function.

主权项

1. A method for providing a biological logic gate comprising the following steps:
subjecting a bistable autoregulatory gene network (GRN) to a noisy background, wherein the noisy background comprises additive noise and multiplicative noise; identifying adjustable parameters of the GRN; using a modified logical stochastic resonance (LSR) paradigm to determine values of the GRN parameters which result in the GRN performing different logic gate functions, wherein inputs are encoded as parameters of the GRN such that an undesired potential well of a potential function, U(x) nearly disappears and using stochastic resonance for cases where the undesired potential well cannot be removed from the potential function, U(x); limiting a parameter interval of the GRN to adjust the GRN to conform to the modified LSR paradigm; and setting the parameter values of the GRN such that the GRN is synthesized to perform a first logic gate function.