| 摘要 |
Provided is a rapid release tablet which is excellent in binding capability and disintegrability and also excellent in storage stability, etc. More specifically, the present invention relates to a granulated composite which includes low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight and D-mannitol, wherein the D-mannitol contains 0.9% by weight or less of D-sorbitola, and to a rapid release tablet including the granulated composite and a drug, and to a method for producing the granulated composite which comprises the steps of: mixing low-substituted hydroxypropyl cellulose having a degree of hydroxypropoxy substitution of from 5 to 16% by weight, first D-mannitol, and water to obtain an aqueous dispersion; and granulating while adding the aqueous dispersion to second D-mannitol, wherein the first D-mannitol and the second D-mannitol contain 0.9% by weight or less of D-sorbitol in total. |
