RECOMBINANT MYCOBACTERIUM ENCODING A HEPARIN BINDING HEMAGGLUTININ (HBHA) FUSION PROTEIN AND USES THEREOF

摘要

Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin binding hemagglutinin (HBHA) fusion protein are provided as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc is post translationally methylated and is highly antigenic.