High Dynamic Range Detector Correction Algorithm

摘要

Systems and methods are provided to perform dead time correction. An observed ion count rate is obtained using a non-paralyzable detection system of a mass spectrometer. The detection system includes an ion detector, a comparator/discriminator, a mono-stable circuit and a counter. The non-paralyzable detection system exhibits dead time extension at high count rates. The extension of the dead time occurs because the mono-stable circuit requires a rising edge to trigger and can only be triggered again after the output pulse from the comparator/discriminator has gone low. This allows a second comparator/discriminator pulse arriving just before the end of the dead time started by a first comparator/discriminator pulse to extend the dead time to the trailing edge of the second comparator/discriminator pulse. A true ion count rate is calculated by performing dead time correction of the observed ion count rate.

主权项

1. A system for performing dead time correction for a non-paralyzable detection system of a mass spectrometer that exhibits dead time extensions which are the result of a characteristic of the non-paralyzing electronics at high count rates, comprising:
a non-paralyzable detection system of a mass spectrometer that includes an ion detector, a comparator/discriminator, a mono-stable circuit, and a counter, wherein the mono-stable circuit requires a rising edge of a pulse from the comparator/discriminator to trigger and can only be triggered again after the pulse has gone low allowing a second comparator/discriminator pulse arriving just before the end of a dead time started by a first comparator/discriminator pulse to extend the dead time to a trailing edge of the second comparator/discriminator pulse; and a processor in data communication with the counter that
receives an observed ion count from the counter,calculates an observed ion count rate from the observed ion count, andperforms dead time correction of the observed ion count rate using an equation for a true ion count rate of a non-paralyzable detection system that additionally includes an adjustment factor function that accounts for the extension of the dead time.