发明名称 |
HYPER-GLYCOSYLATED ANTIBODIES WITH SELECTIVE FC RECEPTOR BINDING |
摘要 |
Means for improving the effector functions of current immunotherapeutic antibodies through targeted hyper-glycosylation of the antibody Fc region are disclosed, as well as antibody variants having hyper-glycosylated Fc regions. Fc receptor-mediated effector functions have been shown to be a critical contributor to the efficacies of numerous therapeutic antibodies currently in clinical use. Targeted hyper-glycosylation of antibodies has the potential to significantly improve current immunotherapies for cancer. |
申请公布号 |
WO2015074063(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
WO2014US66197 |
申请日期 |
2014.11.18 |
申请人 |
UNIVERSITY OF MARYLAND, BALTIMORE;SUNDBERG, ERIC J.;TRASTOY BELLO, BEATRIZ |
发明人 |
SUNDBERG, ERIC J.;TRASTOY BELLO, BEATRIZ |
分类号 |
C07K16/18;C12N15/13;C12P21/00 |
主分类号 |
C07K16/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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