| 发明名称 |
NON-HUMAN ANIMALS HAVING A HUMANIZED B-CELL ACTIVATING FACTOR GENE |
| 摘要 |
Non-human animals, cells, methods and compositions for making and using the same are provided, wherein the non-human animals and cells comprise a humanized B-cell activating factor gene. Non-human animals and cells that express a human or humanized B-cell activating factor protein from an endogenous B-cell activating factor locus are described. |
| 申请公布号 |
US2015143558(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201414537312 |
申请日期 |
2014.11.10 |
| 申请人 |
Regeneron Pharmaceuticals, Inc. |
发明人 |
McWhirter John;Gurer Cagan;Macdonald Lynn;Murphy Andrew J. |
| 分类号 |
A01K67/027;G01N33/50;C12N15/85 |
主分类号 |
A01K67/027 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A non-human animal expressing a Baff polypeptide comprising the extracellular portion of a human BAFF protein linked to the intracellular portion of a Baff protein of the non-human animal. |
| 地址 |
Tarrytown NY US |
