FLUORESCENCE-BASED SENSOR WITH MULTIPLE INDICATOR GRAFTS

摘要

A system including a sensor and a transceiver and configured to determine a concentration of an analyte in a medium of a living animal. The sensor may include first and second signal photodetectors and first and second reference photodetectors, which may each be covered by an associate filter. The first photodetector may receive light emitted from first and second grafts, respectively. The grafts may receive excitation light from one or more light sources. The transceiver may receive signals from the photodetectors of the sensor and may determine the analyte concentration based on the received signals.

主权项

1. An optical sensor, the sensor comprising:
a sensor housing; a first graft covering at least a first portion of the sensor housing; first indicator molecules embedded in the first graft and having a first optical characteristic responsive to the concentration of the analyte; a second graft covering at least a second portion of the sensor housing; second indicator molecules embedded in the second graft and having a second optical characteristic responsive to the concentration of the analyte; a substrate; a first light source fabricated in or mounted on the substrate and configured to emit first excitation light to the first indicator molecules in the first graft; a first signal photodetector fabricated in or mounted on the substrate and configured to receive first emission light emitted by the first indicator molecules; a first reference photodetector fabricated in or mounted on the substrate and configured to receive first reference light; a second light source fabricated in or mounted on the substrate and configured to emit second excitation light to the second indicator molecules in the second graft; a second signal photodetector fabricated in or mounted on the substrate and configured to receive second emission light emitted by the second indicator molecules; and a second reference photodetector fabricated in or mounted on the substrate and configured to receive second reference light.