Organ Mounted Electronics

摘要

Provided are devices and methods capable of interfacing with biological tissues, such as organs like the heart, in real-time and using techniques which provide the ability to monitor and control complex physical, chemical, biochemical and thermal properties of the tissues as a function of time. The described devices and methods utilize micro scale sensors and actuators to spatially monitor and control a variety of physical, chemical and biological tissue parameters, such as temperature, pH, spatial position, force, pressure, electrophysiology and to spatially provide a variety of stimuli, such as heat, light, voltage and current.

主权项

1. A device for interfacing with an internal biological tissue, the device comprising:
a flexible and stretchable substrate having an inner surface and an external surface, wherein the inner surface defines an enclosure to enclose the internal biological tissue; a flexible and stretchable electronic device or device component comprising one or more sensors, actuators or both supported by the inner surface of the flexible or stretchable substrate; the sensors, the actuators or both comprising one or more inorganic semiconductor components, one or more metallic components, or one or more inorganic semiconductor components and one or more metallic components; wherein at least a portion of the inorganic semiconductor components, the metallic components or both have a thickness less than or equal to 500 microns; and wherein the flexible and stretchable substrate and the electronic device or device component provide a net bending stiffness of the system low enough such that the inner surface of the substrate is capable of establishing conformal contact with at least 70% of an outer surface of the internal biological tissue.