摘要 |
Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η20, Form F of HCl salt of Compound (1)·3Η20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject. |
申请人 |
VERTEX PHARMACEUTICALS INCORPORATED |
发明人 |
NTI-ADDAE, KWAME, W.;WALDO, MICHAEL;O'NEIL, SIMON, ADAM;VAN ALSTEN, JOHN, GREGG;MACIKENAS, DAINIUS;MUDUNURI, PRAVEEN;SHI, YI;LEDEBOER, MARK, WILLEM;JURKAUSKAS, VALDAS;MEDEK, ALES;JONES, STEVEN;BYRN, RANDAL;ASMAL, MOHAMMED;ROBERTSON, SARAH, MARIE;TSAI, WANJUNG |