发明名称 INHIBITORS OF INFLUENZA VIRUSES REPLICATION
摘要 Polymorphic forms of Compound (1) or a pharmaceutically acceptable salt thereof, wherein Compound (1) is represented by the following structural formula: are Form A of HCl salt of Compound (1)·1/2Η20, Form F of HCl salt of Compound (1)·3Η20, Form D of HCl salt of Compound (1), Form A of Compound (1), and Form A of tosylate salt of Compound (1). Such polymorphic forms are employed for treating influenza, inhibiting the replication of influenza viruses, or reducing the amount of influenza viruses in a biological sample or in a subject.
申请公布号 WO2015073476(A1) 申请公布日期 2015.05.21
申请号 WO2014US65114 申请日期 2014.11.12
申请人 VERTEX PHARMACEUTICALS INCORPORATED 发明人 NTI-ADDAE, KWAME, W.;WALDO, MICHAEL;O'NEIL, SIMON, ADAM;VAN ALSTEN, JOHN, GREGG;MACIKENAS, DAINIUS;MUDUNURI, PRAVEEN;SHI, YI;LEDEBOER, MARK, WILLEM;JURKAUSKAS, VALDAS;MEDEK, ALES;JONES, STEVEN;BYRN, RANDAL;ASMAL, MOHAMMED;ROBERTSON, SARAH, MARIE;TSAI, WANJUNG
分类号 C07D403/04;A61K31/506;A61P31/16;C07D471/04 主分类号 C07D403/04
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