FIXING TISSUE SAMPLES USING NITROGEN-CONTAINING COMPOUNDS THAT RELEASE ALDEHYDES

摘要

A method (100) for fixing at least one tissue sample (1) is carried out using a tissue processor (10). The tissue sample (1) is introduced at a first temperature level and a first pressure level into a fixing reagent (2) containing at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde. The tissue sample (1) is left in the fixing reagent (2) for a fixing time period during which the fixing reagent (2) is brought to a second temperature level above the first temperature level and/or to a second pressure level above the first pressure level. A concentration in the fixing reagent (2) of the nitrogen-containing compound is ascertained using at least one concentration measuring device (14) of the tissue processor (10), and a signal is outputted on the basis of a measured value of the at least one concentration measuring device (14).

主权项

1. A method (100) for fixing at least one tissue sample (1), which method is carried out using a tissue processor (10), the method comprising the steps of:
introducing at least one tissue sample (1) into a fixing reagent (2) at a first temperature level and at a first pressure level, wherein the fixing reagent (2) contains at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of at least one aldehyde; leaving the at least one tissue sample (1) in the fixing reagent (2) at least for a fixing time period, wherein during the fixing time period the fixing reagent (2) having the at least one tissue sample (1) introduced thereinto is brought, during the fixing time period, to a second temperature level above the first temperature level and/or to a second pressure level above the first pressure level; and ascertaining a concentration in the fixing reagent (2) of the at least one nitrogen-containing compound capable of pressure- and/or temperature-dependent release of the at least one aldehyde using at least one concentration measuring device (14) of the tissue processor (10), and outputting a signal on the basis of a measured value of the at least one concentration measuring device (14).