| 发明名称 |
METHODS FOR DETECTING INACTIVATION OF THE HOMOLOGOUS RECOMBINATION PATHWAY (BRCA1/2) IN HUMAN TUMORS |
| 摘要 |
The invention relates to methods for detecting inactivation of the DNA Homologous Recombination pathway in a patient, and in particular for detecting BRCA1 inactivation. |
| 申请公布号 |
US2015140122(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201314402254 |
申请日期 |
2013.06.06 |
| 申请人 |
Institut Curie ;INSERM (Institut National de la Sante et de la Recherche) |
发明人 |
Stern Marc-Henri;Manie Elodie;Popova Tatiana |
| 分类号 |
C12Q1/68;A61K31/502;A61K31/55;A61K31/131;A61K31/454;A61K31/5025;A61K33/24;A61K31/282;A61K31/166;A61K31/407 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for predicting tumor deficiency in the DNA homologous recombination (HR) pathway in a patient suffering from cancer, comprising the step of quantifying the number of rearrangements in the genomic DNA of a tumor sample obtained from said patient, wherein the number of rearrangements corresponds to the number, per genome, of breakpoints resulting in segments of at least 3 megabases. |
| 地址 |
Paris FR |
