| 发明名称 |
GENERATION OF MULTIFUNCTIONAL AND MULTIVALENT POLYPEPTIDE COMPLEXES WITH COLLAGEN XVIII TRIMERIZATION DOMAIN |
| 摘要 |
The invention relates to the design of trimeric polypeptide complexes using polypeptide structural elements derived from the collagen XVIII protein, and their use in diagnostic and therapeutic systems in vivo and in vitro. The invention also relates to nucleic acids and vectors useful for producing said trimeric complexes. |
| 申请公布号 |
US2015139991(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201114344650 |
申请日期 |
2011.10.17 |
| 申请人 |
Álvarez Vallina Luis;Cuesta Martinez Ángel;Sainz Pastor Noelia;Sanz Alcober Laura |
发明人 |
Álvarez Vallina Luis;Cuesta Martinez Ángel;Sainz Pastor Noelia;Sanz Alcober Laura |
| 分类号 |
C07K14/78;C07K16/18 |
主分类号 |
C07K14/78 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A trimeric polypeptide complex comprising three monomer polypeptides, wherein (i) each of said monomer polypeptides comprises a collagen XVIII trimerizing structural element (XVIIITSE) and (ii) at least one of said monomer polypeptides is covalently linked to at least one heterologous moiety, wherein said heterologous moiety is positioned C-terminally to said monomer polypeptide. |
| 地址 |
Madrid ES |
