| 发明名称 |
COMPOSITIONS WHICH REGULATE THE EPITHELIAL BRUSH BORDER Na+/H+ EXCHANGER NHE3 AND THEIR METHODS OF USE IN GASTROINTESTINAL DISEASE |
| 摘要 |
A synthetic peptide modeled on the IRCX binding area of NHE3, is a competitive inhibitor of the IRCX and both stimulates basal NHE3 activity and prevents elevated Ca2+ and cAMP inhibition of NHE3. Methods of its preparation and use in the prevention and/or treatment of gastrointestinal disease, such as diarrhea are provided. |
| 申请公布号 |
US2015139956(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201314400904 |
申请日期 |
2013.05.17 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY ;THE PENNSYLVANIA STATE UNIVERSITY |
发明人 |
Donowitz Mark;Zachos Nicholas Constantine;Van Rossum Damian Brett;Patterson Randen |
| 分类号 |
C07K14/47;A61K45/06;A61K35/741;A61K38/17 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A sodium/hydrogen Exchanger 3 (NHE3) Inhibitory Regulatory Complex ICRX Competing Peptide (ICRX-CP), or a functional portion or analog or derivative thereof. |
| 地址 |
Baltimore MD US |
