| 摘要 |
PROBLEM TO BE SOLVED: To provide a method that determines efficacy of a TNFα inhibitor, such as a TNFα antibody, or an antigen-binding portion thereof, for treating ankylosing spondylitis (AS).SOLUTION: A method comprises: comparing a pre-determined level of a collagen degradation biomarker and/or a synovitis biomarker from an AS patient following treatment using a human TNFα antibody with a known standard level of the collagen degradation biomarker and/or the synovitis biomarker associated with the disease state; and assessing whether the patient's post-treatment collagen degradation biomarker and/or synovitis biomarker level following the treatment of the patient is lower than the known standard level of the collagen degradation biomarker and/or synovitis biomarker, and a collagen degradation biomarker and/or synovitis biomarker from the patient following treatment of the patient is lower than the known standard level, thereby efficacy of the human TNFα antibody for the treatment of AS is indicated. |
