HYDROPHOBIC CERAGENIN COMPOUNDS AND DEVICES INCORPORATING SAME

摘要

A hydrophobic cationic steroidal anti-microbial (ceragenin) compound forms an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face. The hydrophobic CSA also includes a hydrophobic substituent that gives the ceragenin compound a C Log P value of at least 6.0, 6.25, 6.5, 7.5, 8.5, or 10.

主权项

1. A hydrophobic cationic steroidal anti-microbial (CSA) compound comprising:
a sterol structure comprising four fused carbon rings; at least one cationic substituent attached to each of at least three of the four fused carbon rings so as to form an amphiphilic compound having a hydrophobic sterol face and a hydrophilic cationic face; and at least one hydrophobic substituent attached to at least one of the fused carbon rings; wherein the CSA compound has a structure as in Formula (1): where q=0 and p=1; two or three of R3, R7, and R12 independently include a cationic group; R17 is a hydrophobic substituent which includes a heteroatom and a hydrocarbon group of at least 9 carbon atoms distal to the heteroatom; and R1, R2, R4-R6, R8-R16 are any substituent, with the proviso that R16 does not form a fused ring with R17 and the CSA compound is not CSA-135.