发明名称 |
PHOSPHODIESTERASE 1-TARGETING TRACERS AND METHODS |
摘要 |
Tracers targeting phosphodiesterase1 for use in gamma radiation detection-based diagnostic techniques, particularly gamma-emitter labeled tracers for SPECT and positron emitter-labeled compositions for PET are disclosed. Radio-labeled multiple novel scaffolds as PDE1 inhibitors such as substituted pyrazolo-pyrimidin-4-one derivatives, biomarkers for phosphodiesterase 1 [PDE1) in vivo, methods for developing novel therapies for PDE1-implicated conditions such as pulmonary arterial hypertension (PAH), Central Nervous System (CNS) and Cardiovascular (CV) disorders, and methods of detection and treatment are also disclosed. |
申请公布号 |
US2015139903(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
US201414492879 |
申请日期 |
2014.09.22 |
申请人 |
LI Peng;WENNOGLE Lawrence;ZHAO Jun;ZHENG Hailin |
发明人 |
LI Peng;WENNOGLE Lawrence;ZHAO Jun;ZHENG Hailin |
分类号 |
A61K51/04;G01T1/164;C07D473/06;G01T1/29 |
主分类号 |
A61K51/04 |
代理机构 |
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代理人 |
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主权项 |
1. A radiolabeled PDE1 inhibitor. |
地址 |
New York NY US |