SUBMICRON NATAMYCIN PARTICLE

摘要

The invention relates to a submicron particle comprising a polyene antifungal compound and a hydrophobic polymer wherein said polyene antifungal compound is molecularly dissolved in, and/or incorporated by said hydrophobic polymer and to a method to prepare the particle comprising the steps of providing a polymer phase comprising a hydrophobic polymer dissolved in a first water-miscible solvent; providing a polyene antifungal compound phase comprising polyene antifungal compound dissolved in a second water-miscible solvent; mixing the polymer phase and the polyene antifungal compound phase to produce a solvent phase; adding the polymer phase to an aqueous solvent to produce a suspension comprising submicron polyene antifungal compound particles; and optionally isolating said polyene antifungal compound particles. The polyene antifungal compound can be used in the preservation of a crop, a feed product or food product.