AGOMELATINE SULFURIC ACID COMPLEX, AND PREPARATION METHOD AND APPLICATION THEREOF

摘要

The present invention relates to an Agomelatine sulfuric acid complex in formula (I) and the preparation method thereof (HX=H2SO4, RSO3H (R=CH3, Ph, 4-CH3Ph)). The solubility of the Agomelatine sulfuric acid complex obtained by the method of the present invention is significantly improved compared with Agomelatine, has good stability and higher purity, and is suitable for application in finished-product medicinal preparations. The preparation process is quite simple, and a product with high purity can be obtained without special operations.;

主权项

1. An Agomelatine sulfuric acid complex as in formula I: wherein HX is selected from H2SO4 or CH3SO3H.