| 主权项 |
1. A compound of Formula I or a pharmaceutically acceptable salt thereof: wherein, X and Y each independently are —O—, —S—, —S(O)—, —S(O)2—, —C(O)—, —NR′—, —CHOR′—, —CHNHR′—, —CHNR′R″— or —CR′R″—; or X and Y together form —CH═CH—; wherein R′ and R″ each independently are H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-6 alkoxyl, C1-6 alkylamino, hydroxyl C1-6 alkyl, C1-6 halogenated alkyl, hydroxyl, acyl, aryl or heteroaryl; and when R′ and R″ form a chiral center at substitution site, the compound of Formula I can be a single R or S configuration or a racemate; R1 represents 1, 2, 3 or 4 substituents optionally existing on the benzene ring, independently being H, alkyl, alkoxyl, halogen, acyl, alkenyl, alkynyl, hydroxyl, cyano, amino, alkylamino, dialkylamino, cyano alkyl, hydroxyl alkyl, halogenated alkyl, acylamino, alkylthio, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; R2 is alkyl, alkoxyl, halogen, acyl, alkenyl, alkynyl, hydroxyl, cyano, amino, alkylamino, dialkylamino, acylamino, alkylthio, cycloalkyl, hydroxyl alkyl, halogenated alkyl, cyano alkyl, heterocycloalkyl, aryl or heteroaryl; Q and W each independently are N or CR; wherein R is H, halogen (e.g., fluorine, chlorine, bromine, iodine), cyano, amino, hydroxyl, C1-6 alkyl, C1-6 alkoxyl, hydroxyl C1-6 alkyl, C1-6 halogenated alkyl, cyano C1-6 alkyl, C1-6 alkylamino, C1-6dialkylamino, C2-6 alkenyl or conjugated alkenyl, C2-6 alkynyl or conjugated alkynyl, acyl, acylamino, alkylthio, cycloalkyl, heterocycloalkyl, aryl or heteroaryl; R5 and R6 together with carbon atoms linked to them form 5- or 6-membered saturated, partially unsaturated carbocyclic ring or heterocyclic ring, or aromatic ring or aromatic heterocyclic ring forming a conjugated system, wherein the heterocyclic ring or aromatic heterocyclic ring optionally contains 1, 2, 3 or 4 heteroatoms independently selected from N, O or S; the ring is optionally substituted with 1, 2, 3 or 4 R3; or R5 and R6 each independently are H, alkyl, alkoxyl, hydroxyl alkyl, halogen, halogenated alkyl, carboxyl, ester group, acyl, alkenyl, alkynyl, hydroxyl, cyano, amino, alkylamino, dialkylamino, acylamino, alkylthio, cycloalkyl, heterocycloalkyl, aryl or heteroaryl, which are optionally substituted with 1, 2, 3 or 4 R3; R3 independently is H, C1-6 alkyl, C1-6 alkoxyl, fluorine, chlorine, bromine, iodine, acyl, C2-6 alkenyl, C2-6 alkynyl, hydroxyl, cyano, amino, C1-6 alkylamino, acylamino, C1-6alkylthio, C3-6 cycloalkyl, heterocycloalkyl, C5-10aryl or heteroaryl; n1=0, 1 or 2; and n2=0 or 1. |
