| 发明名称 |
MICROSPHERE-BASED DELIVERY AND EX VIVO MANIPULATION OF DENDRITIC CELLS FOR AUTOIMMUNE THERAPIES |
| 摘要 |
The present invention relates to tolerogenic mammalian dendritic cells (iDCs) and methods for the production of tolerogenic DCs. In addition, the present invention provides methods for administration of tolerogenic dendritic cells as well as particles containing oligonucleotides to mammalian subjects. Enhanced tolerogenicity in a host can be useful for treating inflammatory and autoimmune related diseases, such as type 1 diabetes. |
| 申请公布号 |
US2015139965(A1) |
申请公布日期 |
2015.05.21 |
| 申请号 |
US201414546755 |
申请日期 |
2014.11.18 |
| 申请人 |
University of Pittsburgh - Of the Commonwealth System of Higher Education |
发明人 |
Giannoukakis Nick;Trucco Massimo M. |
| 分类号 |
A61K35/15;A61K9/00 |
主分类号 |
A61K35/15 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for restoration of blood glucose to a pre-diabetic level in a pediatric mammal comprising:
administering two or more subcutaneous injections of tolerogenic dendritic cells at one or more injection sites proximal to a pancreas in said pediatric mammal, wherein said blood glucose is restored to said pre-diabetic level for a period of at least twenty four hours. |
| 地址 |
Pittsburgh PA US |
