USE OF MICRORNA MARKERS FOR DIAGNOSIS OF THYROID TUMORS AND A DIAGNOSTIC PANEL CONTAINING SUCH MARKERS.

摘要

The present invention relates to a method for diagnosing thyroid cancer and benign thyroid lesion in a patient in vitro. The said method comprises: - providing a biological sample collected from a patient, - determining the amount of one or more miRNAs selected from the group consisting of miR-146b-5p, miR-146b-3p, miR-22l-5p, miR-221-3p, miR-222-5p, miR-222- 3p, miR-181a-5p and miR-182-5p in a biolgical sample - comparing the obtained microRNA expression level to the control group, in which method the patient is diagnosed for cancer or/and benign lesion if the level of miRNA expression in the biological sample is altered relative to the expression level observed in samples of biological fluids from healthy subjects. The invention also relates to the medical use of abovementioned miRNAs and of diagnostic kits allowing for determination of miRNAs in a biological sample.