Detector arrangement for blood culture bottles with colorimetric sensors

摘要

(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date W O 2013/109267 Al 25 July 2013 (25.07.2013) WI POI PCT (51) internationall Patent Classification: (81) Designated States (unless otherwise indicated. for ever G01N33/48(200601) kind of naionalprotection available) AE, AG AL, AM AO, AT, AU, AZ, BA, BB, BG, BH, BR, BW, BY, BZ, (21) InternatIonal Applicadon Number: CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, DO, PCT/US2OT2/02T733 DZ, EC. EE, EG. ES, FI, (Bl, GD, GL, ll. GM, GT, IN, (22) International Illg Dite: HR, HU, ID, IL, IN, IS, JP, KI, KG, KM, KN, KP, KR, 18 January2012(18.0L20l2) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NO, NI, NO, NZ, (25) Filing Language: English OM, P , PP, PL, PT, QA, RO, RS, RU, RW, SC, SD, (26) Publication Language: English SE, SO, SK, SL, SM ST, SV. SY, TH, TJ, TM, TN, TR, Tf, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (71) Applicant (for all designated States except US): 110. MERIEUX, INC. (US/USI; 100 Rodolphe street, (84) Designated States (unles otherwise indwied for ewiv Durham, NC 27712 (US). kind of regional protection available): ARIPO (BW, OH, ON KE, LR, LS, MW, MZ NA, RW, SD, SL, SZ, TZ, (72) Inventor; and U6, ZM, ZW), Eurnsian (AM, AZ, BY, KG, KZ, MD, RU, (75) Inventor/Applicant (for US on/): CLAY, Bradford, G. TJ, TM), European (AL, AT, BE, BG, CII, CY, CZ, DE, [US/US]; 1723 Timber Ridge Estates Drive,. Wildwood, DK, IE, ES, F, FR, GB, OR, IR, HIIIU, IE, IS, IT, LT, LU. MO 63011 (US). LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, (74) Agents: KIEFER. Phillip, R. et al.; Biomerieux, hIc., Pa- SM, TR), OAPI (BF, B, CF, CG, C. CM, GA, GN, GQ, ent Department, '00 Rodolphe Sireo, Durham, NC 27712 GW, ML, MR, NE, SN, TD, TO). (US). Published: - with international search report (Art 21(3)) (54) TItle: DETECTOR ARRANGEMENT FOR BLOOD CULTURE BOTTLES WITH COLORIMETRIC SENSORS (57) Abstract: A detector arrangement is disclosed for a MAI blood culture bottle incorporating a colorimetric sensor which is subject to change of color due to change in pH or C02 of a sample medium within the blood culture bottle. Th detector margemnent includes a sensor LED illumit - ing the colorimetric sensor, a reference LED) ilhnninating the colorimetric sensor, a control circuit for selectively md al ternately activating the sensor LED and the reference LED, and a photodetector, lie photodetector measures reflectance from the colorinmetric sensor during the selective and altern ating illumination of the colorimetric sensor with the sensor LED and the reference LEI) and generates intensity signals, 1 The refrence LED is selected to have a peak wavelength of illuinattiion such that the intensity signals of the photode lector from illumination by the reference LED are not sub sintially athcted by changes in the color of the coloriretric sensor.