发明名称 |
IONIZABLE CATIONIC LIPID FOR RNA DELIVERY |
摘要 |
What is described is a compound of formula (I), wherein R1 and R2 are the same or different, each a linear or branched alkyl with 1-9 carbons, or an alkenyl or alkynyl with 2 to 11 carbon atoms; L1 and L2 are the same or different, each a linear alkyl having 5 to 18 carbon atoms, or form a heterocycle with N; X1 is a bond, or is -CO-O- whereby L2-CO-O-R2 is formed; X2 is S or O; L3 is a bond or a lower alkyl, or form a heterocycle with N; R3 is a lower alkyl; and R4 and R5 are the same or different, each a lower alkyl; or a pharmaceutically acceptable salt thereof. |
申请公布号 |
WO2015074085(A1) |
申请公布日期 |
2015.05.21 |
申请号 |
WO2014US66242 |
申请日期 |
2014.11.18 |
申请人 |
ARCTURUS THERAPEUTICS, INC. |
发明人 |
PAYNE, JOSEPH, E.;CHIVUKULA, PADMANABH |
分类号 |
C07C271/22;A61K9/127;C07C235/12;C07C323/52;C07C333/04;C07J31/00;C12N15/11 |
主分类号 |
C07C271/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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