发明名称 |
ENHANCING ACTIVITY OF CAR T CELLS BY CO-INTRODUCING A BISPECIFIC ANTIBODY |
摘要 |
The present invention provides compositions and methods for treating cancer in a human. The invention includes administering a T cell, genetically modified to express a chimeric antigen receptor (CAR), a bispecific antibody, or a combination thereof to a subject. The CAR and bispecific antibody of the invention can comprise a human antibody, a humanized antibody, or antigen-binding fragments thereof. |
申请公布号 |
EP2872526(A2) |
申请公布日期 |
2015.05.20 |
申请号 |
EP20130817144 |
申请日期 |
2013.07.12 |
申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
JUNE, CARL, H.;ZHAO, YANGBING;LIU, XIAOJUN |
分类号 |
C07K14/05;A61K35/17;A61K39/00;C07K16/28;C07K16/46 |
主分类号 |
C07K14/05 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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