发明名称 |
CRYSTALLINE FORM I OF TYROSINE KINASE INHIBITOR DIMALEATE AND PREPARATION METHODS THEREOF |
摘要 |
<p>Provided are crystalline Form I of (R,E)-N-(4-(3-chloro-4-(pyridin-2-yl -methoxy)-phenylamino)-3-cyano-7-ethoxy-quinolin-6-yl)-3-(1-methylpyrr olidin-2-yl) propenamide dimaleate (called SHR1258 dimaleate for short), preparation methods thereof and pharmaceutical composition containing the same. Said crystalline Form I of SHR1258 dimaleate has good crystal stability and chemical stability, and can be used in preparation of medicaments for treating diseases relevant to EGFR receptor tyrosine kinase or HER-2 receptor tyrosine kinase.</p> |
申请公布号 |
EP2873664(A1) |
申请公布日期 |
2015.05.20 |
申请号 |
EP20130817593 |
申请日期 |
2013.06.04 |
申请人 |
JIANGSU HENGRUI MEDICINE CO. LTD. |
发明人 |
SUN, PIAOYANG;WU, GUAILI;YUAN, BO;CHEN, YONGJIANG |
分类号 |
C07D401/14;A61K31/4709;A61P35/00 |
主分类号 |
C07D401/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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