QUINOLINE-LIKE COMPOUND SUBSTITUTED BY PHOSPHORUS-CONTAINING GROUP, METHOD FOR PREPARING IT, THERAPEUTIC COMPOSITION CONTAINING THIS COMPOUND AND USING IT

摘要

FIELD: medicine, pharmaceutics.SUBSTANCE: invention refers to quinolines substituted by phosphorus-containing group of formulaand applicable in medicine, wherein Z representsVand Vare independently specified in hydrogen or halogen; one of R and R` represent phosphorus-containing substitute Q; the other one is specified in hydrogen or methoxyl; wherein the phosphorus-containing substitute Q representsA represents O; L represents Calkyl; J represents NH or Cheterocycloalkyl and J is optionally substituted by G; X is absent or represents -C(=O)-; X is absent or represents Calkyl; each of Rand Rare independently specified in Calkyl or Calkoxy; Grepresents Calkyl, RS(=O)-, RC(=O)- or RRNC(=O)-; R, Rand Rare independently specified in 3 or Calkyl; m is equal to 0-2.EFFECT: there are presented new protein kinase inhibitors effective for treating the diseases associated with abnormal protein kinase activity.20 cl, 42 ex, 8 tbl, 3 dwg