发明名称 |
BISPECIFIC ASYMMETRIC HETERODIMERS COMPRISING ANTI-CD3 CONSTRUCTS |
摘要 |
Disclosed herein are isolated multi-specific heteromultimer constructs that bind to CD3 expressed on T-cells and to an antigen expressed on B-cells. The multi-specific heteromultimer constructs are capable of bridging T- and B-cells and mediating killing of B-cells. The multi-specific heteromultimer constructs are based on a heterodimeric Fc scaffold or on a segmented albumin scaffold. Also disclosed herein are multi-specific heteromultimer constructs that bind to HER2 and HER3. |
申请公布号 |
EP2872170(A2) |
申请公布日期 |
2015.05.20 |
申请号 |
EP20130816697 |
申请日期 |
2013.07.13 |
申请人 |
ZYMEWORKS, INC. |
发明人 |
DIXIT, SURJIT BHIMARAO;SPRETER VON KREUDENSTEIN, THOMAS;NG, GORDON, YIU KON;WEISSER, NINA E. |
分类号 |
C07K16/46;A61K39/395;C07K16/28 |
主分类号 |
C07K16/46 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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