| 发明名称 | Methods for metabolic imaging | ||
| 摘要 | The present embodiments disclose the preparation of hyperpolarized 13C dialkyl succinate compounds and hyperpolarized 13C dialkyl fumarate compounds and their use in real time, in vivo metabolic imaging of the TCA cycle. | ||
| 申请公布号 | US9034928(B2) | 申请公布日期 | 2015.05.19 |
| 申请号 | US201414157519 | 申请日期 | 2014.01.17 |
| 申请人 | IMAGNX, Inc. | 发明人 | Millward Niki Zacharias;Bhattacharya Pratip |
| 分类号 | C07C69/347;A61K49/10;C07C69/40;C07C69/60;G01R33/46;G01R33/56 | 主分类号 | C07C69/347 |
| 代理机构 | Benesch, Friedlander, Coplan, & Aronoff, LLC | 代理人 | Benesch, Friedlander, Coplan, & Aronoff, LLC ;Kern Benjamen E.;Anderson Kraig K. |
| 主权项 | 1. A method for determining a metabolic state of a patient, comprising: detecting one or more hyperpolarized metabolic products of a hyperpolarized composition by magnetic resonance, the one or more hyperpolarized metabolic products formed by metabolism of the hyperpolarized composition in the patient or a tissue sample thereof, the hyperpolarized composition comprising at least one of a hyperpolarized dialkyl 13C succinate compound or a hyperpolarized dialkyl 13C fumarate compound; and determining the metabolic state of the patient according to the one or more hyperpolarized metabolic products detected by the magnetic resonance. | ||
| 地址 | San Francisco CA US | ||