Sulfated oxysterol and oxysterol sulfation by hydroxysterol sulfotransferase promote lipid homeostasis and liver proliferation

摘要

Methods and compositions for the prevention and treatment of liver damage or disease in a subject in need thereof are provided. The methods involve providing the sulfated oxysterol 25-hydroxycholesterol-3-sulfate (25HC3S) to the subject e.g. by 1) administering 25HC3S to the subject; or 2) overexpressing, in the subject, the hydroxysterol sulfotransferase enzyme SULT2B1b, which catalyzes the sulfation of 25-hydroxycholesterol (25HC) to form 25HC3S.

主权项

1. A method for promoting liver cell proliferation or liver tissue regeneration in a subject, comprising:
i) identifying a subject in need of at least one of liver cell proliferation and liver tissue regeneration, and ii) elevating a level of 25-hydroxycholesterol-3-sulfate (25HC3S) in said subject by administering to said subject a composition comprising
25HC3S anda physiologically compatible carrier, wherein said subject does not have hyperlipidemia, and wherein said elevating promotes proliferation of liver cells or regeneration of liver tissue in said subject.