发明名称 |
Tetrahydrotriazine compounds for treating diseases associated with AMPK activity |
摘要 |
The invention relates to compounds of formula (I) wherein the radicals R1 to R6 have the meaning according to claim 1, and/or physiologically acceptable salts thereof, for the prophylactic or therapeutic treatment and/or monitoring of physiological and/or pathological conditions that are associated with the activity of AMP-activated protein kinase (AMPK). Another object of the invention concerns the use of said compounds for enhancing glucose homeostasis, improving podocytopathy and/or decreasing the production of reactive oxygen species (ROS). The invention also relates to a method for in-vitro diagnosing diabetic nephropathy and a method for screening compounds that reduce podocytopathy, in each case by applying synaptopodin as biomarker.; |
申请公布号 |
US9035048(B2) |
申请公布日期 |
2015.05.19 |
申请号 |
US200912998848 |
申请日期 |
2009.12.11 |
申请人 |
POXEL |
发明人 |
Cravo Daniel;Hallakou-Bozec Sophie;Mesangeau Didier;Elbawab Samer |
分类号 |
C07D251/10;A61K31/53;A61P35/00 |
主分类号 |
C07D251/10 |
代理机构 |
Nixon & Vanderhye P.C. |
代理人 |
Nixon & Vanderhye P.C. |
主权项 |
1. A method for treating a mammal for prostate cancer, said method comprising administering a therapeutically effective amount of a compound of formula (I) and/or a physiologically acceptable salt thereof to a mammal in need of such treating wherein the compound of formula (I) is 5,6-dihydro-4-dimethylamino-2-imino-6-methyl-1,3,5-triazine and/or the physiologically acceptable hydrochloride salt thereof. |
地址 |
Lyons FR |