Process for annealing amorphous atorvastatin

摘要

Processes for annealing amorphous atorvastatin is described. Pharmaceutical compositions and formulations containing annealed amorphous atorvastatin are also described.

主权项

1. A process for annealing amorphous atorvastatin at elevated temperature comprising heating at ambient pressure amorphous atorvastatin in an essentially solvent-free system wherein no additional solvent is added to a temperature of between approximately 50° C. to approximately 140° C.; holding said temperature for approximately 30 minutes to approximately 12 hours; and cooling the resulting annealed amorphous atorvastatin.