Phenyl carbamate compounds for use in preventing or treating stroke

摘要

A phenyl carbamate compound; a composition for treating and/or preventing stroke containing the phenyl carbamate compound or a pharmaceutically acceptable salt thereof as an active ingredient; a method of treating and/or preventing stroke comprising administering the phenyl carbamate compound or a pharmaceutically acceptable salt thereof to a patient in need of stroke treatment; and a use of the phenyl carbamate compound or a pharmaceutically acceptable salt thereof in treating and/or preventing stroke, are provided.

主权项

1. A method of treating stroke comprising administering a pharmaceutically effective amount of a phenyl carbamate compound represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof, to a subject in need thereof: wherein X is a halogen; n is an integer from 1 to 5; R 1 is a linear or branched alkyl group of C1-C4; A is hydrogen or a carbamoyl derivative represented by B is hydrogen, a carbamoyl derivative represented by  trialkyl silyl groups, trialkylaryl silyl groups (wherein the total number of alkyl and aryl groups is three), or a trialkyl silyl ether group, wherein each alkyl group is independently selected from the group consisting of linear, branched, or cyclic C1-C4 alkyl groups, and each aryl group is independently selected from the group consisting of C5-C8 aryl groups; A and B are not carbamoyl derivatives at same time; and R2 and R3 may be the same as or different from each other, and independently selected from the group consisting of hydrogen, a linear or branched alkyl group of C1-C4, a cycloalkyl group of C3-C8, and benzyl group.