Polypeptide for treating or preventing adhesions

摘要

The described invention provides compositions and methods for treating or preventing adhesions in a subject in need thereof, the method comprising the step of (a) administering an adhesion-reducing amount of a composition comprising a polypeptide having the amino acid sequence YARAAARQARAKALARQLGVAA [SEQ ID NO: 1] or a functional equivalent thereof and a carrier. The methods are clinically useful for reducing formation of adhesions initially and for therapeutic treatment of existing scars.

主权项

1. A pharmaceutical composition to reduce incidence or extent of a scar tissue binding together two anatomic surfaces normally separated from each other that develops after surgery, inflammation or injury in a subject in need thereof, the composition comprising a therapeutic amount of a polypeptide consisting of amino acid sequence YARAAARQARAKALARQLGVAA [SEQ ID NO: 1] and a pharmaceutically acceptable carrier, the composition being characterized by a therapeutic effect of the therapeutic amount to reduce incidence, severity, or both, of the scar tissue without impairing normal healing.