发明名称 Composition and methods for treating glioblastoma
摘要 The disclosure provides methods of treating glioblastoma, methods of screening for compounds that treat glioblastoma, and pharmaceutical compositions useful the treatment of glioblastoma.;
申请公布号 US9034895(B2) 申请公布日期 2015.05.19
申请号 US201113818026 申请日期 2011.08.22
申请人 University of Washington Through its Center for Commercialization 发明人 Stella Nephi;Kline Toni
分类号 C07D401/04;C07D209/12;C07D219/12;C07D401/06;C07D403/06;C07D471/04;C07D471/10;G01N33/94 主分类号 C07D401/04
代理机构 McDonnell Boehnen Hulbert & Berghoff LLP 代理人 McDonnell Boehnen Hulbert & Berghoff LLP
主权项 1. A compound of formula: or pharmaceutically acceptable salts, wherein X is CH or N; R11 is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, halogen, —NO2, —CN, —OR15, or —NR16R17, each being optionally substituted with one to four R20; R12 is H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, halogen, —NO2, —CN, —OR15, or —NR16R17, each being optionally substituted with one to four R20; R14 and R13 taken together with the atoms to which they are attached form a 5-, 6-, or 7-membered heterocyclyl group optionally substituted with one to four R20; R15, R16, and R17 are independently H, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl R18 and R19 are each independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, halogen, —NO2, —CN, —OR15, or —NR16R17, each being optionally substituted with one to four R20, R20 is halogen, —CN, —OH, —NO2, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, C1-C6 haloalkyl, C1-C6 alkoxy, or C1-C6 haloalkoxy; and m is an integer 1 or 2.
地址 Seattle WA US