Policosanol nanoparticles

摘要

The present invention provides nanoparticulate policosanol, and octacosanol formulations including these particles, as a well as methods of using the particles and formulations for treatment and prophylaxis of various diseases and conditions.

主权项

1. A composition comprising nanoparticles of policosanol, wherein each nanoparticle comprises:
(a) a policosanol fraction comprising about 50% to 69% octacosanol; and (b) a stabilizer fraction comprising tocopheryl polyethylene glycol (1000) succinate (“TPGS”), wherein the ratio of octacosanol:stabilizer fraction ranges from about 1:1.6 to about 1:3.5 and the nanoparticles have a size between about 40 nm and about 100 nm in diameter and wherein at least 99% of the nanoparticles have a particle size of less than about 70 nm as determined by a light scattering method.