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1. A compound of the formula (IA):or a pharmaceutically acceptable salt thereof;wherein:
R1 is H, hydroxyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, perhaloalkyl, acyl, acyloxy, carbonylalkoxy, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted aralkyl, C1-C8 perhaloalkoxy, alkoxy, aryloxy, —SH, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl or carbonylalkylenealkoxy; each R2a and R2b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, hydroxyl, alkoxy, nitro, substituted or unsubstituted amino, acyloxy, acylamino, aryl, heteroaryl, cycloalkyl, heterocyclyl, or R2a and R2b are taken together with the carbon to which they are attached to form a carbonyl moiety or a cycloalkyl moiety; each R3a and R3b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, hydroxyl, alkoxy, nitro, substituted or unsubstituted amino, acyloxy, acylamino, aryl, heteroaryl, cycloalkyl, heterocyclyl, or R3a and R3b are taken together with the carbon to which they are attached to form a carbonyl moiety or a cycloalkyl moiety; each R4a and R4b is independently H, substituted or unsubstituted C1-C8 alkyl, halo, cyano, nitro, substituted or unsubstituted amino, hydroxyl, alkoxy, acyloxy, acylamino, aryl, heteroaryl, cycloalkyl, heterocyclyl, or R4a and R4b are taken together with the carbon to which they are attached to form a carbonyl moiety or a cycloalkyl moiety; R5 is H or unsubstituted C1-C8 alkyl; each X1, X2 and X3 is independently CH or CR6, provided that at least one of X1, X2 and X3 is CR6; m and n are each 1; o and p are each 0; each R6 is independently hydroxyl, nitro, cyano, halo, C1-C8 perhaloalkyl, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C2-C8 alkenyl, substituted or unsubstituted C2-C8 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 perhaloalkoxy, substituted or unsubstituted C1-C8 alkoxy, substituted or unsubstituted aryloxy, carboxyl, carbonylalkoxy, —SH, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aralkyl, thioalkyl, substituted or unsubstituted amino, acylamino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aminosulfonyl, sulfonylamino, sulfonyl, carbonylalkylenealkoxy, alkylsulfonylamino or acyl; each R8a, R8b, R8c, and R8d is independently H, hydroxyl, alkoxy, halo, substituted or unsubstituted C1-C8 alkyl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C2-C8 alkenyl, C1-C8 perhaloalkyl, carboxyl, carbonylalkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, C1-C8 alkyl substituted with a carbonylalkoxy, carboxyl or acylamino moiety,
or is taken together with a geminal R8(a-d) to form a substituted or unsubstituted methylene moiety or a moiety of the formula —OCH2CH2O—, or is taken together with a geminal R8(a-d) and the carbon to which they are attached to form a carbonyl moiety or a cycloalkyl moiety,or is taken together with a vicinal R8(a-d) and the carbon atoms to which they are attached to form a substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl, or substituted or unsubstituted heterocyclyl moiety,or is taken together with a vicinal R8(a-d) to form a bond provided when an R8(a-d) is taken together with a vicinal R8(a-d) to form a bond, the geminal R8(a-d) is other than hydroxyl; and Q is substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted C3-C8 cycloalkyl, substituted or unsubstituted C3-C8 cycloalkenyl, substituted or unsubstituted heterocyclyl, aminoacyl, acyloxy, carboxyl, cyano, alkynyl, aminocarbonylalkoxy, acylamino, or is a group of the formula —CR9═CR10aR10b, wherein R9 is H or a substituted or unsubstituted C1-C8 alkyl and R10a and R10b are taken together with the carbon to which they are attached to form a substituted or unsubstituted cycloalkyl, cycloalkenyl or heterocyclyl moiety;
wherein heterocyclyl refers to a saturated or unsaturated non-aromatic group having 1 to 10 annular carbon atoms and 1 to 4 annular heteroatoms selected from the group consisting of nitrogen, sulfur, and oxygen, and having a single ring or multiple condensed rings, wherein the multiple condensed rings, where present, may be fused, spiro, bridged, or any combination thereof, and wherein one or more of the fused multiple condensed rings, where present, can be aryl or heteroaryl, and wherein the heterocyclyl moiety may be connected to the parent structure at either a non-aromatic ring position or at an aromatic ring position;heteroaryl refers to an unsaturated aromatic carbocyclic group having 1 to 10 annular carbon atoms and at least one annular heteroatom selected from the group consisting of nitrogen, oxygen, and sulfur, and having a single ring or multiple condensed rings, wherein the multiple condensed rings, where present, may or may not be aromatic, and wherein the heteroaryl moiety may be connected to the parent structure at either an aromatic ring position or at a non-aromatic ring position;substituted alkyl refers to an alkyl group having 1 to 5 substituents selected from the group consisting of alkoxy, acyl, acyloxy, carbonylalkoxy, acylamino, amino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aryl, heteroaryl, aryloxy, cyano, halo, hydroxyl, nitro, carboxyl, thiol, thioalkyl, alkenyl, alkynyl, heterocyclyl, aralkyl, aminosulfonyl, sulfonylamino, sulfonyl, oxo, and carbonylalkylenealkoxy;substituted alkenyl refers to an alkenyl group having 1 to 5 substituents selected from the group consisting of alkoxy, acyl, acyloxy, carbonylalkoxy, acylamino, amino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aryl, heteroaryl, aryloxy, cyano, halo, hydroxyl, nitro, carboxyl, thiol, thioalkyl, alkyl, alkynyl, heterocyclyl, aralkyl, aminosulfonyl, sulfonylamino, sulfonyl, oxo, and carbonylalkylenealkoxy;substituted alkynyl refers to an alkynyl group having 1 to 5 substituents selected from the group consisting of alkoxy, acyl, acyloxy, carbonylalkoxy, acylamino, amino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aryl, heteroaryl, aryloxy, cyano, halo, hydroxyl, nitro, carboxyl, thiol, thioalkyl, alkyl, alkenyl, heterocyclyl, aralkyl, aminosulfonyl, sulfonylamino, sulfonyl, oxo, and carbonylalkylenealkoxy;substituted heterocyclyl refers to a heterocycle group having 1 to 3 substituents selected from the group consisting of alkoxy, acyl, acyloxy, carbonylalkoxy, acylamino, amino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aryl, heteroaryl, aryloxy, cyano, halo, hydroxyl, nitro, carboxyl, thiol, thioalkyl, alkyl, alkenyl, alkynyl, aralkyl, aminosulfonyl, sulfonylamino, sulfonyl, oxo, and carbonylalkylenealkoxy;substituted aryl refers to an aryl group having 1 to 5 substituents selected from the group consisting of alkoxy, acyl, acyloxy, carbonylalkoxy, acylamino, amino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aryl, heteroaryl, aryloxy, cyano, halo, hydroxyl, nitro, carboxyl, thiol, thioalkyl, alkyl, alkenyl, alkynyl, heterocyclyl, aralkyl, aminosulfonyl, sulfonylamino, sulfonyl, oxo, and carbonylalkylenealkoxy;substituted heteroaryl refers to a heteroaryl group having 1 to 5 substituents selected from the group consisting of alkoxy, acyl, acyloxy, carbonylalkoxy, acylamino, amino, aminoacyl, aminocarbonylamino, aminocarbonyloxy, aryl, heteroaryl, aryloxy, cyano, halo, hydroxyl, nitro, carboxyl, thiol, thioalkyl, alkyl, alkenyl, alkynyl, heterocyclyl, aralkyl, aminosulfonyl, sulfonylamino, sulfonyl, oxo, and carbonylalkylenealkoxy; andsubstituted amino refers to the group —NRaRb, where either (a) each Ra and Rb group is independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, and heterocyclic, provided that both Ra and Rb groups are not H; or (b) Ra and Rb are joined together with the nitrogen atom to form a heterocyclic ring. |
